Oral Liquid Stoppers
Food-grade butyl/EPDM rubber stoppers for oral liquids—safe, taste-neutral, and highly sealing, designed for children’s syrups, vitamins, and functional beverages with full regulatory compliance.
Our oral liquid pharmaceutical stoppers are engineered to meet the highest standards of safety, stability, and user-friendliness for sensitive liquid formulations such as pediatric syrups, herbal extracts, probiotics, and vitamin solutions.
Material Safety & Purity:
Made from food/pharmaceutical-grade butyl rubber or EPDM, the stoppers comply with GB 4806, USP Class VI, and European Pharmacopoeia standards—ensuring no cytotoxicity or oral irritation. Heavy metal migration is strictly controlled (≤0.005 mg/dm²), and they are free from phthalates and residual solvents. With ≤0.3% adsorption of active ingredients (e.g., flavonoids, peptides), dose accuracy is preserved. Critically, they do not alter taste—sweetness or bitterness varies by ≤5%—enhancing patient adherence, especially in children and elderly users. Full material traceability supports NMPA and FDA compliance.
Superior Sealing & Preservation:
High elasticity ensures a compression set ≤7%, achieving a 99.95% leak-proof seal even under inversion or shaking. Oxygen permeability is ≤0.1 ml/(m²·24h·atm), and moisture transmission ≤0.12 g/(m²·24h), extending shelf life to 1–3 years. The smooth, non-porous surface limits microbial adhesion to ≤1 CFU/unit—ideal for high-sugar syrups. Compatible with nitrogen flushing and stable from –10°C (frozen probiotics) to 60°C (pasteurization), the stoppers maintain integrity across storage conditions. Paired with aluminum-plastic or easy-tear caps, they provide dual protection against dust and contamination during home use or transport.
User-Centric Design:
Opening force ≤30 N enables easy access for children and seniors. Anti-stick design prevents tearing or residue. Select models feature pre-pierced holes or puncture-friendly zones for straw insertion. Non-slip textures, rounded edges, and compatibility with dosing cups enhance safety and precision. Re-sealable versions support multi-dose use without leakage.
Manufacturing & Logistics Efficiency:
Available in 5–50 mL sizes, compatible with PET, HDPE, and glass bottles, and optimized for high-speed lines (≥300 bottles/min). Custom colors (e.g., orange, blue) reduce medication errors. Lightweight (15% weight reduction) and tear-resistant (≥15 MPa), with ≤0.03% breakage in transit.
| Category | Specification / Feature |
|---|---|
| Base Material | Food/pharma-grade Butyl Rubber or EPDM |
| Compliance Standards | GB 4806, USP Class VI, EP |
| Heavy Metal Migration | ≤0.005 mg/dm² (Pb, As, Hg, etc.) |
| Plasticizers / Solvents | None (phthalate-free, solvent-free) |
| Active Ingredient Adsorption | ≤0.3% (e.g., flavonoids, peptides) |
| Taste Stability | Sweetness/bitterness variation ≤5% after prolonged contact |
| Microbial Limit | ≤10 CFU per stopper (select grades EO-sterilizable) |
| Traceability | Full batch traceability; CoA provided; NMPA/FDA compliant |
| Compression Set | ≤7% |
| Oxygen Permeability | ≤0.1 ml/(m²·24h·atm) |
| Water Vapor Transmission | ≤0.12 g/(m²·24h) |
| Microbial Adhesion | ≤1 CFU per stopper |
| Inert Gas Compatibility | Yes (nitrogen flushing supported) |
| Temperature Range | –10°C to 60°C (stable after thermal cycling) |
| Seal Integrity | 99.95% pass rate; no leakage under inversion/vibration |
| Annual Seal Degradation | ≤2% at 25°C/60% RH |
| Opening Force | ≤30 N |
| Straw Compatibility | Available with pre-pierced hole or puncture zone |
| Re-sealability | Supported in multi-dose versions |
| Edge Design | Rounded, no sharp corners |
| Size Range | 5 mL, 10 mL, 15 mL, 20 mL, 30 mL, 50 mL |
| Bottle Material Compatibility | PET, HDPE, Glass |
| Automation Throughput | ≥300 bottles/minute |
| Color Options | Customizable (e.g., orange, blue) for drug differentiation |
| Tear Strength | ≥15 MPa |
| Breakage Rate (Logistics) | ≤0.03% |
| Weight Reduction | ~15% lighter vs. conventional stoppers |
| Special Features | Optional alignment ring, vent groove, anti-slip texture |